Chronic Lymphocytic Leukaemia

About the condition 

Chronic leukaemia is used to describe the type of cancer that tends to progress slowly over the course of many years. People with chronic leukaemia often show few symptoms for many years. This means that the condition is often diagnosed coincidentally, during routine check-ups or blood tests for other issues. Chronic leukaemia is further classified according to the type of white blood cells affected by cancer – chronic lymphocytic leukaemia (CLL) affects the lymphocyte cells.

All types of leukemia originate in the bone marrow, which is the spongy material found inside bones and contains a specialised type of cell called stem cells. CLL is more common in older people, with most cases occurring in people over 60 years of age*. For reasons that are unknown, men are more likely to develop chronic lymphocytic leukaemia than women.


In its early stages, chronic lymphocytic leukaemia doesn’t usually cause any noticeable symptoms. As the condition develops, symptoms can include:

  • repeated infections that occur over a short space of time
  • tiredness due to a lack of red blood cells (anaemia)
  • unusual bleeding and bruising
  • fever
  • night sweats
  • bone pain
  • weight loss
  • swollen spleen
  • swollen lymph nodes (glands)

If any of these symptoms apply to you, or if you have any concerns about similar symptoms, it is essential that you see your doctor at once, as your chances of recovery are much higher if your cancer is diagnosed early.

Specialist care

If you are referred to CCL for diagnosis, your consultant or oncologist will advise you as to which tests are relevant. Once CLL is suspected, or if any symptoms are shown, tests to diagnose include:

  • A physical examination to check for swollen glands, a swollen spleen or any signs of abnormal bleeding
  • A blood test, to measure the numbers of different types of blood cell
  • A CT scan, which shows a 3D image of the area being looked at
  • An X-ray which is when low level radiation is used to create an image of the body
  • An Ultrasound scan which uses high frequency sound waves to look inside the body and produce live images on a computer display.
  • A bone marrow biopsy, during which a haematologist will take a small sample of bone marrow to examine under a microscope
  • Genetic testing, such as Fluorescence In Situ Hybridisation (FISH) can also be carried out on blood and bone marrow samples to help identify abnormalities in the leukaemia genes
  • A lymph node biopsy, where samples are taken from any enlarged lymph nodes to attempt to discover which specific strain of CLL is present, to further the efficiency of treatment.


At CCL, patients with CLL are treated by a specialist multidisciplinary team headed by Professor Ray Powles, CBE. This team works together to create a treatment plan to suit the individual needs of the patient. As most people diagnosed with chronic lymphocytic leukaemia don’t have symptoms, immediate treatment isn’t usually recommended. Some people can live for years or decades with chronic lymphocytic leukaemia without developing symptoms or needing treatment, as there is no advantage to starting treatment before symptoms appear.

In such cases, a policy of “watchful waiting” is usually recommended, which involves regular visits to your doctor and blood tests so that your condition can be closely monitored.

Once symptoms are present, treatment usually involves:

  • Radiotherapy, which is where high-energy rays are used to destroy the cancer cells.
  • Chemotherapy, which involves the use of chemical agents which are toxic to cancer cells, destroying them and preventing them from spreading to different areas. This can be given by injection or in tablet form.
  • A bone marrow or stem cell transplant, which is a possible alternative if chemotherapy has been unsuccessful.

Treatment can’t cure chronic lymphocytic leukaemia completely, but it can slow its progression and lead to remission (periods where there are no signs or symptoms).

Support Services

We offer a wide range of services for patients, as well as their loved ones, designed to make a very difficult time as easy as possible, and to give our patients the best treatment and support possible. Our support services include a specialist counsellingspecialist physiotherapygroup sessions and much more. You can find the full range of our support services here.

We’ll be with you every step of the way.

Book now

If you have any questions about chronic leukaemia or would like to book an appointment with one of our chronic leukaemia specialists, complete this form online or call 020 8247 3351

Chronic Lymphocytic Leukaemia Consultants


Cancer Centre London

Parkside Hospital

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